Protective effects of B.W. 501 C 67 and B.W. 204 C 67 against lethal effects of exudates from burnt rat skin.

Rocha e Silva and Rosenthal (1) have reported that the exudates from burnt rat skin contain histamine, bradykinin, adenosine derivatives and possibly serotonin and other as yet unidentified pharmacologically active and toxic substances. Hodson (2) has reported the peripheral antiserotonin activity of B.W. 501 C 67 (α-anilino-N-2-m-chlorophenoxypropyl acetamidine hydrochloride monohydrate) and B.W. 204 C 67 (S-m-methylanilino-N-2-mmethoxy phenoxy propyl acetamidine hydriodide) and Rao (3) reported on the presence of central antiserotonin activity of these compounds. Rao (4) also reported that two newer antihistaminic and antiserotonin compounds, cyproheptadine and BC 105, possess significant protective effect against the lethal effects of exudates from burnt rat skin. In the present communication, an attempt has been made to determine whether or not B.W. 501 C 67 and B.W. 204 C 67 have got any protective effect against the toxicity of the exudates.